Gene Information
Gene NameSIRT2
OrganismHomo sapiens (Human)
Gene Length389
Protein NamesNAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
Target Namenad-dependent deacetylase sirtuin-2
Target TypePatented-recorded target
Gene Age>4290 ( ENSG00000068903 )
3 ( ENSG00000283100 )
Evolutionary StageEukaryota
AlphaFoldDBQ8IXJ6
Gene CardSIRT2
Uniprot IDQ8IXJ6
PfamPF02146
In ASDyes
Allosteric Predictionyes (1.000039445)
Ortholog in AnimalsAlpaca_ SIRT2 ( ortholog_one2one )
Dog_ SIRT2 ( ortholog_one2one )
GuineaPig_ SIRT2 ( ortholog_one2one )
Macaque_ SIRT2 ( ortholog_one2one )
Mouse_ Sirt2 ( ortholog_one2one )
Pig_ SIRT2 ( ortholog_one2one )
Rat_ Sirt2 ( ortholog_one2one )
Rabbit_ SIRT2 ( ortholog_one2one )
OhnologsNA
ParalogsSIRT7, SIRT4, SIRT1, SIRT3, SIRT5, SIRT6
TissueNA
Tissue SpecificityIsoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1J8F  (X-ray  1.70A  )  3ZGO  (X-ray  1.63A  )  3ZGV  (X-ray  2.27A  )  4L3O  (X-ray  2.52A  )  4R8M  (X-ray  2.10A  )  4RMG  (X-ray  1.88A  )  4RMH  (X-ray  1.42A  )  4RMI  (X-ray  1.45A  )  4RMJ  (X-ray  1.87A  )  4X3O  (X-ray  1.50A  )  4X3P  (X-ray  1.80A  )  4Y6L  (X-ray  1.60A  )  4Y6O  (X-ray  1.60A  )  4Y6Q  (X-ray  1.90A  )  5D7O  (X-ray  1.63A  )  5D7P  (X-ray  1.76A  )  5D7Q  (X-ray  2.01A  )  5DY4  (X-ray  1.77A  )  5DY5  (X-ray  1.95A  )  5FYQ  (X-ray  3.00A  )  5G4C  (X-ray  2.10A  )  5MAR  (X-ray  1.89A  )  5MAT  (X-ray  2.07A  )  5Y0Z  (X-ray  2.00A  )  5Y5N  (X-ray  2.30A  )  5YQL  (X-ray  1.60A  )  5YQM  (X-ray  1.74A  )  5YQN  (X-ray  1.60A  )  5YQO  (X-ray  1.48A  )  6L65  (X-ray  1.80A  )  6L66  (X-ray  2.17A  )  6L71  (X-ray  2.11A  )  6L72  (X-ray  2.50A  )  6NR0  (X-ray  2.45A  )  6QCN  (X-ray  2.23A  )  7BOS  (X-ray  1.70A  )  7BOT  (X-ray  1.70A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24177535}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8VDQ8}. Cytoplasm {ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24681946}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12620231}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17726514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17726514}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17488717}. Midbody {ECO:0000269|PubMed:17726514}. Chromosome {ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:23468428}. Perikaryon {ECO:0000250|UniProtKB:Q8VDQ8}. Cell projection {ECO:0000250|UniProtKB:Q8VDQ8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8VDQ8}. Myelin membrane {ECO:0000250|UniProtKB:Q8VDQ8}. Note=Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac) (PubMed:17726514, PubMed:23468428). Colocalizes with KMT5A at mitotic foci (PubMed:23468428). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody (PubMed:17488717). Colocalizes with microtubules (PubMed:12620231). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (PubMed:17726514). Colocalizes with EP300 in the nucleus (PubMed:24177535). Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells (PubMed:23908241). Deacetylates FOXO3 in the cytoplasm (By similarity). Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat (By similarity). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (By similarity). Colocalizes with alpha-tubulin in neuronal growth cone (By similarity). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (By similarity). Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (By similarity). Colocalizes with PARD3 in internodal region of axons (By similarity). Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24177535}.;
[Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic. {ECO:0000269|PubMed:24177535}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic. {ECO:0000269|PubMed:24177535}.;
[Isoform 5]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the nucleus. {ECO:0000269|PubMed:24177535}.
Mouse PG classificationNA
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