| Gene Information | |
|---|---|
| Gene Name | KCNS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 526 |
| Protein Names | Potassium voltage-gated channel subfamily S member 1 (Delayed-rectifier K(+) channel alpha subunit 1) (Voltage-gated potassium channel subunit Kv9.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000124134 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96KK3 |
| Gene Card | KCNS1 |
| Uniprot ID | Q96KK3 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | no (-0.421360099) |
| Ortholog in Animals | Alpaca_ KCNS1 ( ortholog_one2one ) Dog_ KCNS1 ( ortholog_one2one ) GuineaPig_ KCNS1 ( ortholog_one2one ) Macaque_ KCNS1 ( ortholog_one2one ) Mouse_ Kcns1 ( ortholog_one2one ) Pig_ KCNS1 ( ortholog_one2one ) Rat_ Kcns1 ( ortholog_one2one ) Rabbit_ KCNS1 ( ortholog_one2one ) |
| Ohnologs | KCNS2, KCNF1, KCNV1, KCNG4, KCNS3, KCNB2 |
| Paralogs | KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | cerebral.cortex |
| Tissue Specificity | Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis (PubMed:10484328). {ECO:0000269|PubMed:10484328}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs734784 rs7264544 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10484328}; Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328). {ECO:0000269|PubMed:10484328}. |
| Mouse PG classification | NA |
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