| Gene Information | |
|---|---|
| Gene Name | SLC30A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000170385 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9Y6M5 |
| Gene Card | SLC30A1 |
| Uniprot ID | Q9Y6M5 |
| Pfam | PF01545 |
| In ASD | no |
| Allosteric Prediction | no (-0.341397418) |
| Ortholog in Animals | Alpaca_ SLC30A1 ( ortholog_one2one ) Dog_ SLC30A1 ( ortholog_one2one ) GuineaPig_ SLC30A1 ( ortholog_one2one ) Macaque_ SLC30A1 ( ortholog_one2one ) Mouse_ Slc30a1 ( ortholog_one2one ) Pig_ SLC30A1 ( ortholog_one2one ) Rat_ Slc30a1 ( ortholog_one2one ) Rabbit_ SLC30A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC30A2, SLC30A3, SLC30A10, SLC30A7, SLC30A4, SLC30A6, SLC30A8, SLC30A5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:31471319}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:32441444}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to the plasma membrane is regulated by cellular zinc status. Recruitment to the plasma membrane from an internal pool is stimulated by zinc while in absence of zinc the plasma membrane pool is endocytosed and degraded (PubMed:31471319). Localizes to the basolateral surface of enterocytes (By similarity). Localizes to zinc-containing intracellular vesicles in macrophages (PubMed:32441444). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Mouse PG classification | NA |
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