| Gene Information | |
|---|---|
| Gene Name | HELB |
| Organism | Homo sapiens (Human) |
| Gene Length | 1087 |
| Protein Names | DNA helicase B (hDHB) (EC 3.6.4.12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000127311 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NG08 |
| Gene Card | HELB |
| Uniprot ID | Q8NG08 |
| Pfam | PF13538 |
| In ASD | no |
| Allosteric Prediction | no (-0.883910392) |
| Ortholog in Animals | Alpaca_ HELB ( ortholog_one2one ) Dog_ HELB ( ortholog_one2one ) GuineaPig_ HELB ( ortholog_one2one ) Macaque_ HELB ( ortholog_one2one ) Mouse_ Helb ( ortholog_one2one ) Pig_ HELB ( ortholog_one2one ) Rat_ Helb ( ortholog_one2one ) Rabbit_ HELB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | YTHDC2, DHX40, DHX34, DHX32, DHX57, DHX30, DHX29, DHX36, DHX15, DHX35, DHX9, DHX38, DQX1, DHX16, DHX33, TDRD9, DHX8, DHX37 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain. {ECO:0000269|PubMed:12181327}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35605829 rs4430553 rs35138454 rs58589183 rs1185244 rs1168312 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15146062}. Cytoplasm {ECO:0000269|PubMed:15146062}. Chromosome {ECO:0000269|PubMed:26774285}. Note=Predominantly nuclear (PubMed:15146062). Phosphorylation at Ser-967 by CDK2 during the G1/S transition results in its nuclear export into the cytoplasm as cells approach and progress through S phase (PubMed:15146062). Following DNA damage, recruited to sites of double-strand breaks by the RPA complex (PubMed:26774285). Recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment (PubMed:22194613). {ECO:0000269|PubMed:15146062, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:26774285}. |
| Mouse PG classification | NA |
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