| Gene Information | |
|---|---|
| Gene Name | UNG |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) |
| Target Name | uracil-dna glycosylase |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000076248 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P13051 |
| Gene Card | UNG |
| Uniprot ID | P13051 |
| Pfam | PF03167 |
| In ASD | no |
| Allosteric Prediction | yes (0.333427132) |
| Ortholog in Animals | Alpaca_ UNG ( ortholog_one2one ) Alpaca_ UNG ( ortholog_one2many ) Dog_ UNG ( ortholog_one2many ) Macaque_ UNG ( ortholog_one2one ) Mouse_ Ung ( ortholog_one2one ) Pig_ UNG ( ortholog_one2one ) Rat_ Ung ( ortholog_one2one ) Rabbit_ UNG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.160000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AKZ (X-ray 1.57A ) 1DPU (NMR - ) 1EMH (X-ray 1.80A ) 1EMJ (X-ray 2.00A ) 1Q3F (X-ray 1.90A ) 1SSP (X-ray 1.90A ) 1UGH (X-ray 1.90A ) 1YUO (X-ray 1.95A ) 2HXM (X-ray 1.30A ) 2OXM (X-ray 2.50A ) 2OYT (X-ray 2.00A ) 2SSP (X-ray 2.25A ) 3FCF (X-ray 1.84A ) 3FCI (X-ray 1.27A ) 3FCK (X-ray 1.64A ) 3FCL (X-ray 1.70A ) 3TKB (X-ray 1.50A ) 4SKN (X-ray 2.90A ) 5AYR (X-ray 2.40A ) 5JK7 (X-ray 3.49A ) 6VBA (X-ray 1.80A ) 7V7C (EM 3.70A ) |
| DBSNP | rs7488798 rs104894380 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus. |
| Mouse PG classification | HPG |
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