| Gene Information | |
|---|---|
| Gene Name | UNC93B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 597 |
| Protein Names | Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000110057 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9H1C4 |
| Gene Card | UNC93B1 |
| Uniprot ID | Q9H1C4 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.999760076) |
| Ortholog in Animals | Alpaca_ UNC93B1 ( ortholog_one2one ) Dog_ UNC93B1 ( ortholog_one2one ) GuineaPig_ UNC93B1 ( ortholog_one2one ) Macaque_ UNC93B1 ( ortholog_one2one ) Mouse_ Unc93b1 ( ortholog_one2one ) Pig_ UNC93B1 ( ortholog_one2one ) Rat_ Unc93b1 ( ortholog_one2one ) |
| Ohnologs | UNC93B5 |
| Paralogs | UNC93A |
| Tissue | NA |
| Tissue Specificity | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. {ECO:0000269|PubMed:11867227, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7C76 (EM 3.40A ) 7CYN (EM 4.20A ) |
| DBSNP | rs3175471 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}. |
| Mouse PG classification | LPG |
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