| Gene Information | |
|---|---|
| Gene Name | GMPR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000100938 ) 3 ( ENSG00000284752 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9P2T1 |
| Gene Card | GMPR2 |
| Uniprot ID | Q9P2T1 |
| Pfam | PF00478 |
| In ASD | no |
| Allosteric Prediction | yes (0.102796803) |
| Ortholog in Animals | Alpaca_ GMPR2 ( ortholog_one2one ) Dog_ GMPR2 ( ortholog_one2one ) GuineaPig_ GMPR2 ( ortholog_one2one ) Macaque_ GMPR2 ( ortholog_one2one ) Mouse_ Gmpr2 ( ortholog_one2one ) Pig_ GMPR2 ( ortholog_one2one ) Rat_ Gmpr2 ( ortholog_one2one ) Rabbit_ GMPR2 ( ortholog_one2one ) |
| Ohnologs | GMPR |
| Paralogs | IMPDH1, IMPDH2, GMPR |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A7R (X-ray 3.00A ) 2BZN (X-ray 2.15A ) 2C6Q (X-ray 1.70A ) |
| DBSNP | rs34354104 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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