| Gene Information | |
|---|---|
| Gene Name | UNC5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 842 |
| Protein Names | Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000113763 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6ZN44 |
| Gene Card | UNC5A |
| Uniprot ID | Q6ZN44 |
| Pfam | PF00531; PF07679; PF17217; PF00791 |
| In ASD | no |
| Allosteric Prediction | no (-0.639865456) |
| Ortholog in Animals | Alpaca_ UNC5A ( ortholog_one2one ) Dog_ UNC5A ( ortholog_one2one ) GuineaPig_ UNC5A ( ortholog_one2one ) Macaque_ UNC5A ( ortholog_one2one ) Mouse_ Unc5a ( ortholog_one2one ) Pig_ UNC5A ( ortholog_one2one ) Rat_ Unc5a ( ortholog_one2one ) Rabbit_ UNC5A ( ortholog_one2one ) |
| Ohnologs | UNC5B, UNC5D, UNC5C |
| Paralogs | UNC5C, UNC5B, UNC5CL, UNC5D |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4V2A (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:O08721}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08721}. Membrane raft {ECO:0000250|UniProtKB:O08721}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O08721}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. {ECO:0000250|UniProtKB:O08721}. |
| Mouse PG classification | NA |
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