| Gene Information | |
|---|---|
| Gene Name | UNC45A |
| Organism | Homo sapiens (Human) |
| Gene Length | 944 |
| Protein Names | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000140553 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H3U1 |
| Gene Card | UNC45A |
| Uniprot ID | Q9H3U1 |
| Pfam | PF13181; PF11701 |
| In ASD | no |
| Allosteric Prediction | no (-0.716462808) |
| Ortholog in Animals | Alpaca_ UNC45A ( ortholog_one2one ) Dog_ UNC45A ( ortholog_one2one ) GuineaPig_ UNC45A ( ortholog_one2one ) Macaque_ UNC45A ( ortholog_one2one ) Mouse_ Unc45a ( ortholog_one2one ) Pig_ UNC45A ( ortholog_one2one ) Rat_ Unc45a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TTC1, TTC32, SUGT1, TTC4, TOMM34, SPAG1, SGTB, UNC45B, TOMM70, DNAAF4, TTC31, ST13, TTC12, STIP1, SPATA16, SGTA, RPAP3, STUB1 |
| Tissue | NA |
| Tissue Specificity | Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach. {ECO:0000269|PubMed:12119110}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2DBA (NMR - ) |
| DBSNP | rs369103911 rs8041035 rs376117199 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16478993}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16478993}. Nucleus {ECO:0000269|PubMed:16478993}. Note=Predominant in the perinuclear region. Little protein in the nucleus. |
| Mouse PG classification | NA |
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