| Gene Information | |
|---|---|
| Gene Name | UNC13B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1591 |
| Protein Names | Protein unc-13 homolog B (Munc13-2) (munc13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000198722 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14795 |
| Gene Card | UNC13B |
| Uniprot ID | O14795 |
| Pfam | PF00130; PF00168; PF06292 |
| In ASD | no |
| Allosteric Prediction | yes (0.394083235) |
| Ortholog in Animals | Alpaca_ UNC13B ( ortholog_one2many ) Dog_ UNC13B ( ortholog_one2one ) Macaque_ UNC13B ( ortholog_one2one ) Mouse_ Unc13b ( ortholog_one2one ) Pig_ UNC13B ( ortholog_one2one ) Rat_ Unc13b ( ortholog_one2one ) Rabbit_ UNC13B ( ortholog_one2one ) |
| Ohnologs | UNC13A, UNC13C |
| Paralogs | UNC13C, UNC13A |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney cortical epithelial cells and brain. {ECO:0000269|PubMed:9607201}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35199210 rs12339582 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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