| Gene Information | |
|---|---|
| Gene Name | ULK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 472 |
| Protein Names | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) |
| Target Name | serine/threonine-protein kinase ulk3 |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000140474 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6PHR2 |
| Gene Card | ULK3 |
| Uniprot ID | Q6PHR2 |
| Pfam | PF04212; PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.361558538) |
| Ortholog in Animals | Alpaca_ ULK3 ( ortholog_one2one ) Dog_ ULK3 ( ortholog_one2one ) GuineaPig_ ULK3 ( ortholog_one2one ) Macaque_ ULK3 ( ortholog_one2one ) Mouse_ Ulk3 ( ortholog_one2one ) Pig_ ULK3 ( ortholog_one2one ) Rat_ Ulk3 ( ortholog_one2one ) Rabbit_ ULK3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ULK1, ULK2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord. {ECO:0000269|PubMed:19878745}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4WZX (X-ray 1.39A ) 6FDY (X-ray 1.70A ) 6FDZ (X-ray 2.55A ) |
| DBSNP | rs34945944 rs12898397 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745}. Note=Localizes to pre-autophagosomal structure during cellular senescence. |
| Mouse PG classification | NA |
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