| Gene Information | |
|---|---|
| Gene Name | ULK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1050 |
| Protein Names | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) |
| Target Name | serine/threonine-protein kinase ulk1 |
| Target Type | Literature-reported target |
| Gene Age | 987 ( ENSG00000177169 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75385 |
| Gene Card | ULK1 |
| Uniprot ID | O75385 |
| Pfam | PF12063; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.106015981) |
| Ortholog in Animals | Dog_ EP400 ( ortholog_one2one ) GuineaPig_ ULK1 ( ortholog_one2one ) Macaque_ ULK1 ( ortholog_one2one ) Mouse_ Ulk1 ( ortholog_one2one ) Pig_ ULK1 ( ortholog_one2one ) Rat_ Ulk1 ( ortholog_one2one ) Rabbit_ ULK1 ( ortholog_one2one ) |
| Ohnologs | ULK2 |
| Paralogs | ULK3, ULK2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002925(Rat);0.051613(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4WNO (X-ray 1.56A ) 4WNP (X-ray 1.88A ) 5CI7 (X-ray 1.74A ) 6HYO (X-ray 1.07A ) 6MNH (X-ray 1.73A ) 6QAS (X-ray 1.75A ) |
| DBSNP | rs370624303 rs56364352 rs12827141 rs55824543 rs55815560 rs11546871 rs11609348 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}. |
| Mouse PG classification | NA |
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