Gene Information
Gene NameCREB3L2
OrganismHomo sapiens (Human)
Gene Length520
Protein NamesCyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2]
Target NameNA
Target TypeNA
Gene Age1292 ( ENSG00000182158 )
Evolutionary StageEumetazoa
AlphaFoldDBQ70SY1
Gene CardCREB3L2
Uniprot IDQ70SY1
PfamPF00170
In ASDno
Allosteric Predictionno (-0.378673265)
Ortholog in AnimalsAlpaca_ CREB3L2 ( ortholog_one2one )
Dog_ DGKI ( ortholog_one2one )
GuineaPig_ CREB3L2 ( ortholog_one2one )
Macaque_ CREB3L2 ( ortholog_one2one )
Mouse_ Creb3l2 ( ortholog_one2one )
Pig_ CREB3L2 ( ortholog_one2one )
Rat_ Creb3l2 ( ortholog_one2one )
Rabbit_ CREB3L2 ( ortholog_one2one )
OhnologsCREB3L1
ParalogsCREB3L3, ATF6, ATF1, ATF6B, CREB3L4, CREB1, CREB3L1, CREM, CREB3
TissueNA
Tissue SpecificityWidely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart. {ECO:0000269|PubMed:12915480}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs273957 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BH52};
Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.;
[Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.
Mouse PG classificationNA
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