| Gene Information | |
|---|---|
| Gene Name | NPR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 541 |
| Protein Names | Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) |
| Target Name | natriuretic peptide receptor |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000113389 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17342 |
| Gene Card | NPR3 |
| Uniprot ID | P17342 |
| Pfam | PF01094 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000008374) |
| Ortholog in Animals | Alpaca_ NPR3 ( ortholog_one2one ) Dog_ NPR3 ( ortholog_one2one ) Macaque_ NPR3 ( ortholog_one2one ) Mouse_ Npr3 ( ortholog_one2one ) Pig_ NPR3 ( ortholog_one2one ) Rat_ Npr3 ( ortholog_one2one ) Rabbit_ NPR3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADCY8, GUCY1B1, ADCY7, NPR2, ADCY3, GUCY1A1, ADCY1, NPR1, ADCY9, ADCY6, GUCY2C, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, GUCY2F |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.002419(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JDN (X-ray 2.90A ) 1JDP (X-ray 2.00A ) 1YK0 (X-ray 2.40A ) 1YK1 (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30032985}; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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