Gene Information
Gene NamePTPN13
OrganismHomo sapiens (Human)
Gene Length2485
Protein NamesTyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)
Target Namefap-1 messenger rna
Target TypePatented-recorded target
Gene Age645 ( ENSG00000163629 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ12923
Gene CardPTPN13
Uniprot IDQ12923
PfamPF09380; PF00373; PF09379; PF00595; PF00102
In ASDyes
Allosteric Predictionyes (0.85038303)
Ortholog in AnimalsAlpaca_ PTPN13 ( ortholog_one2one )
Dog_ PTPN13 ( ortholog_one2one )
GuineaPig_ PTPN13 ( ortholog_one2one )
Macaque_ PTPN13 ( ortholog_one2one )
Mouse_ Ptpn13 ( ortholog_one2one )
Pig_ PTPN13 ( ortholog_one2one )
Rat_ Ptpn13 ( ortholog_one2one )
Rabbit_ PTPN13 ( ortholog_one2one )
OhnologsNA
ParalogsPTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21
TissueNA
Tissue SpecificityExpressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. {ECO:0000269|PubMed:29043977}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001704(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1D5G  (NMR  -  )  1Q7X  (NMR  -  )  1WCH  (X-ray  1.85A  )  2M0Z  (NMR  -  )  2M10  (NMR  -  )  3LNX  (X-ray  1.64A  )  3LNY  (X-ray  1.30A  )  3PDZ  (NMR  -  )  5GLJ  (X-ray  1.60A  )  7QCX  (NMR  -  )  7QCY  (NMR  -  ) 
DBSNP rs10033029  rs749353184  rs2230600  rs12500797  rs17012064  rs989902  rs34226837 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}.
Mouse PG classificationNA
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