| Gene Information | |
|---|---|
| Gene Name | ITGA8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1063 |
| Protein Names | Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000077943 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P53708 |
| Gene Card | ITGA8 |
| Uniprot ID | P53708 |
| Pfam | PF01839; PF00357; PF08441 |
| In ASD | no |
| Allosteric Prediction | no (-0.375503954) |
| Ortholog in Animals | Alpaca_ ITGA8 ( ortholog_one2one ) Dog_ ITGA8 ( ortholog_one2one ) GuineaPig_ ITGA8 ( ortholog_one2one ) Macaque_ ITGA8 ( ortholog_one2one ) Mouse_ Itga8 ( ortholog_one2one ) Pig_ ITGA8 ( ortholog_one2one ) Rat_ Itga8 ( ortholog_one2one ) Rabbit_ ITGA8 ( ortholog_one2one ) |
| Ohnologs | ITGA2B, ITGA5, ITGAV |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | NA |
| Tissue Specificity | Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level). {ECO:0000269|PubMed:10504498, ECO:0000269|PubMed:7768999}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7895372 rs587777281 rs374664941 rs2298033 rs9333269 rs9333174 rs9333241 rs1041135 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269|PubMed:24439109}. Cell membrane {ECO:0000269|PubMed:24439109}. |
| Mouse PG classification | LPG |
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