| Gene Information | |
|---|---|
| Gene Name | UGT1A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 530 |
| Protein Names | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000242366 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HAW9 |
| Gene Card | UGT1A8 |
| Uniprot ID | Q9HAW9 |
| Pfam | PF00201 |
| In ASD | no |
| Allosteric Prediction | yes (0.44354878) |
| Ortholog in Animals | Dog_ UGT1A6 ( ortholog_one2many ) Mouse_ Ugt1a8 ( ortholog_many2many ) Mouse_ Ugt1a9 ( ortholog_many2many ) Mouse_ Ugt1a10 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | UGT2B15, UGT2B17, UGT2A3, UGT3A1, UGT1A3, UGT1A4, UGT1A5, UGT8, UGT2B4, UGT2B7, UGT3A2, UGT1A1, UGT2A1, UGT2A2, UGT1A6, UGT2B10, UGT2B11, UGT2B28, UGT1A10, UGT1A7, UGT1A9 |
| Tissue | colon, urinary.bladder |
| Tissue Specificity | [Isoform 1]: Expressed in kidney, colon and small intestine (PubMed:18004212). Not expressed in liver (PubMed:18004212). {ECO:0000269|PubMed:18004212}.; [Isoform 2]: Expressed in liver, kidney, colon and small intestine. {ECO:0000269|PubMed:18004212}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs45504099 rs17862841 rs1042597 rs1042597 rs1126803 rs72551325 rs17863762 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:17179145}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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