| Gene Information | |
|---|---|
| Gene Name | UGT1A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 533 |
| Protein Names | UDP-glucuronosyltransferase 1A1 (UGT1A1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-1) (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (UDP-glucuronosyltransferase 1A isoform 1) |
| Target Name | udp-glucuronosyltransferase 1a1 |
| Target Type | Clinical trial target |
| Gene Age | 3 ( ENSG00000241635 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P22309 |
| Gene Card | UGT1A1 |
| Uniprot ID | P22309 |
| Pfam | PF00201 |
| In ASD | yes |
| Allosteric Prediction | yes (1.029182999) |
| Ortholog in Animals | Macaque_ UGT1A1 ( ortholog_one2one ) Mouse_ Ugt1a1 ( ortholog_one2one ) Rat_ Ugt1a3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UGT2B15, UGT2B17, UGT2A3, UGT3A1, UGT1A3, UGT1A4, UGT1A5, UGT8, UGT2B4, UGT2B7, UGT3A2, UGT1A10, UGT1A8, UGT1A7, UGT1A9, UGT2A1, UGT2A2, UGT1A6, UGT2B10, UGT2B11, UGT2B28 |
| Tissue | duodenum, liver, small.intestine |
| Tissue Specificity | [Isoform 1]: Expressed in liver, colon and small intestine. Not expressed in kidney, esophagus and skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}.; [Isoform 2]: Expressed in liver, colon, small intestine and kidney. Not expressed in esophagus and skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs111033541 rs72551339 rs4148323 rs56059937 rs587776762 rs72551341 rs72551342 rs72551343 rs35003977 rs35350960 rs754922685 rs72551345 rs397978903 rs758873309 rs72551347 rs62625011 rs72551348 rs750453538 rs139607673 rs1559414817 rs72551351 rs55750087 rs55750087 rs72551352 rs748989741 rs72551353 rs1349037761 rs1283652721 rs72551354 rs901936528 rs367897068 rs28934877 rs72551355 rs778766461 rs72551356 rs758411577 rs1476500325 rs34993780 rs1042709 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:17179145, ECO:0000269|PubMed:17187418}; Single-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17187418}. |
| Mouse PG classification | NA |
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