| Gene Information | |
|---|---|
| Gene Name | UGP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 508 |
| Protein Names | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000169764 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q16851 |
| Gene Card | UGP2 |
| Uniprot ID | Q16851 |
| Pfam | PF01704 |
| In ASD | no |
| Allosteric Prediction | yes (0.456605523) |
| Ortholog in Animals | Alpaca_ UGP2 ( ortholog_one2one ) Dog_ UGP2 ( ortholog_one2one ) GuineaPig_ UGP2 ( ortholog_one2one ) Macaque_ UGP2 ( ortholog_one2one ) Mouse_ Ugp2 ( ortholog_one2one ) Pig_ UGP2 ( ortholog_one2one ) Rat_ Ugp2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UAP1, UAP1L1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in various brain regions. Expressed in amygdala, anterior cingulate cortex, caudate, cerebellar hemisphere, cerebellum, cortex, frontal cortex, hippocampus, hypothalamus, nucleus accumbens, putamen, spinal cord and substantia nigra (PubMed:31820119). Also widely expressed among other tissues, including liver, heart, placenta, lung, kidney, pancreas and skeletal muscle (PubMed:8354390, PubMed:8631325). {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3R2W (X-ray 3.60A ) 3R3I (X-ray 3.57A ) 4R7P (X-ray 3.35A ) |
| DBSNP | rs768305634 rs1130982 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390}. |
| Mouse PG classification | NA |
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