| Gene Information | |
|---|---|
| Gene Name | UGDH |
| Organism | Homo sapiens (Human) |
| Gene Length | 494 |
| Protein Names | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) |
| Target Name | udp-glucose 6-dehydrogenase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000109814 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O60701 |
| Gene Card | UGDH |
| Uniprot ID | O60701 |
| Pfam | PF00984; PF03720; PF03721 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999636825) |
| Ortholog in Animals | Alpaca_ UGDH ( ortholog_one2one ) Dog_ UGDH ( ortholog_one2one ) GuineaPig_ UGDH ( ortholog_one2one ) Macaque_ UGDH ( ortholog_one2one ) Mouse_ Ugdh ( ortholog_one2one ) Pig_ UGDH ( ortholog_one2one ) Rat_ Ugdh ( ortholog_one2one ) Rabbit_ UGDH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970). {ECO:0000269|PubMed:9737970, ECO:0000269|PubMed:9850599}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2Q3E (X-ray 2.00A ) 2QG4 (X-ray 2.10A ) 3ITK (X-ray 2.40A ) 3KHU (X-ray 2.30A ) 3PRJ (X-ray 3.10A ) 3PTZ (X-ray 2.50A ) 3TDK (X-ray 2.80A ) 3TF5 (X-ray 2.30A ) 4EDF (X-ray 2.08A ) 4RJT (X-ray 2.70A ) 5TJH (X-ray 2.05A ) 5VR8 (X-ray 2.00A ) 5W4X (X-ray 2.65A ) 6C4J (X-ray 2.53A ) 6C4K (X-ray 2.65A ) 6C58 (X-ray 2.20A ) 6C5A (X-ray 2.30A ) 6C5Z (X-ray 2.95A ) |
| DBSNP | rs749975104 rs200059198 rs1381665298 rs756467468 rs1186496501 rs775162839 rs113094436 rs770456604 rs201894374 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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