Gene Information
Gene NamePTH1R
OrganismHomo sapiens (Human)
Gene Length593
Protein NamesParathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
Target Nameparathyroid hormone/parathyroid hormone-related peptide receptor
Target TypeNA
Gene Age645 ( ENSG00000160801 )
Evolutionary StageEumetazoa
AlphaFoldDBQ03431
Gene CardPTH1R
Uniprot IDQ03431
PfamPF00002; PF02793
In ASDyes
Allosteric Predictionyes (0.999833912)
Ortholog in AnimalsAlpaca_ PTH1R ( ortholog_one2one )
Dog_ PTH1R ( ortholog_one2one )
GuineaPig_ PTH1R ( ortholog_one2one )
Macaque_ PTH1R ( ortholog_one2one )
Mouse_ Pth1r ( ortholog_one2one )
Pig_ PTH1R ( ortholog_one2one )
Rat_ Pth1r ( ortholog_one2one )
Rabbit_ PTH1R ( ortholog_one2one )
OhnologsNA
ParalogsADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R
Tissuekidney
Tissue SpecificityExpressed in most tissues. Most abundant in kidney, bone and liver. {ECO:0000269|PubMed:8397094}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1BL1  (NMR  3C4M  (X-ray  1.95A  3H3G  (X-ray  1.94A  3L2J  (X-ray  3.24A  4Z8J  (X-ray  0.95A  5EMB  (X-ray  0.85A  6NBF  (EM  3.00A  6NBH  (EM  3.50A  6NBI  (EM  4.00A  7VVJ  (EM  3.20A  7VVK  (EM  3.30A  7VVL  (EM  2.80A  7VVM  (EM  3.20A  7VVN  (EM  3.80A  7VVO  (EM  4.10A 
DBSNP rs121434599  rs121434601  rs121434597  rs121434598  rs121434602  rs121434600 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:8397094};
Multi-pass membrane protein {ECO:0000269|PubMed:20172855}.
Mouse PG classificationNA
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