| Gene Information | |
|---|---|
| Gene Name | UCP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 307 |
| Protein Names | Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin) |
| Target Name | mitochondrial uncoupling protein 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000109424 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P25874 |
| Gene Card | UCP1 |
| Uniprot ID | P25874 |
| Pfam | PF00153 |
| In ASD | no |
| Allosteric Prediction | yes (0.205226771) |
| Ortholog in Animals | Alpaca_ UCP1 ( ortholog_one2one ) Dog_ UCP1 ( ortholog_one2one ) GuineaPig_ UCP1 ( ortholog_one2one ) Macaque_ UCP1 ( ortholog_one2one ) Mouse_ Ucp1 ( ortholog_one2one ) Rat_ Ucp1 ( ortholog_one2one ) Rabbit_ UCP1 ( ortholog_one2one ) |
| Ohnologs | UCP3, UCP2 |
| Paralogs | SLC25A23, SLC25A35, SLC25A38, SLC25A12, SLC25A11, SLC25A22, SLC25A29, UCP3, SLC25A21, SLC25A48, SLC25A42, SLC25A3, SLC25A28, UCP2, SLC25A34, SLC25A15, SLC25A32, SLC25A53, SLC25A4, SLC25A40, SLC25A10, SLC25A18, SLC25A24, SLC25A44, SLC25A31, SLC25A5, SLC25A39, SLC25A36, SLC25A14, SLC25A27, SLC25A1, SLC25A41, SLC25A43, SLC25A47, SLC25A20, SLC25A37, SLC25A13, SLC25A33, SLC25A25, SLC25A26, SLC25A6, SLC25A45, SLC25A2, SLC25A51, SLC25A52, SLC25A30, SLC25A19, SLC25A16, SLC25A17 |
| Tissue | NA |
| Tissue Specificity | Brown adipose tissue. {ECO:0000269|PubMed:3165741}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs45539933 rs2270565 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04633}. |
| Mouse PG classification | LPG |
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