Gene Information
Gene NameADAMTS4
OrganismHomo sapiens (Human)
Gene Length837
Protein NamesA disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)
Target Nameaggrecanase-1
Target TypePatented-recorded target
Gene Age424 ( ENSG00000158859 )
Evolutionary StageEumetazoa
AlphaFoldDBO75173
Gene CardADAMTS4
Uniprot IDO75173
PfamPF17771; PF19236; PF05986; PF01562; PF01421; PF00090
In ASDno
Allosteric Predictionno (-0.52304801)
Ortholog in AnimalsAlpaca_ ADAMTS4 ( ortholog_one2one )
Dog_ ADAMTS4 ( ortholog_one2one )
GuineaPig_ ADAMTS4 ( ortholog_one2one )
Macaque_ ADAMTS4 ( ortholog_one2one )
Mouse_ Adamts4 ( ortholog_one2one )
Pig_ ADAMTS4 ( ortholog_one2one )
Rat_ Adamts4 ( ortholog_one2one )
Rabbit_ ADAMTS4 ( ortholog_one2one )
OhnologsADAMTS8, ADAMTS1, ADAMTS5, ADAMTS15
ParalogsADAMTS5, ADAMTSL2, ADAMTS15, ADAMTS1, ADAMTS19, ADAMTS8, ADAMTSL3, ADAMTS7, THSD4, ADAMTSL4, ADAMTS3, ADAMTS20, ADAMTS6, ADAMTSL5, ADAMTS9, ADAMTS12, ADAMTS14, ADAMTS13, ADAMTSL1, ADAMTS10, ADAMTS16, ADAMTS17, PAPLN, ADAMTS2, ADAMTS18
Tissueadipose.tissue
Tissue SpecificityExpressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278). {ECO:0000269|PubMed:16723216, ECO:0000269|PubMed:23897278}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2RJP  (X-ray  2.80A  )  3B2Z  (X-ray  2.80A  )  4WK7  (X-ray  1.24A  )  4WKE  (X-ray  1.62A  )  4WKI  (X-ray  1.60A  ) 
DBSNP rs17855814  rs34448954  rs17855813  rs17855812  rs17855815  rs17855816  rs4233367  rs11807350 
Subcellular location [CC]Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Mouse PG classificationNA
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