| Gene Information | |
|---|---|
| Gene Name | UCN |
| Organism | Homo sapiens (Human) |
| Gene Length | 124 |
| Protein Names | Urocortin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000163794 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P55089 |
| Gene Card | UCN |
| Uniprot ID | P55089 |
| Pfam | PF00473 |
| In ASD | no |
| Allosteric Prediction | no (-0.007556922) |
| Ortholog in Animals | Alpaca_ UCN ( ortholog_one2one ) Dog_ UCN ( ortholog_one2one ) Macaque_ UCN ( ortholog_one2one ) Mouse_ Ucn ( ortholog_one2one ) Pig_ UCN ( ortholog_one2one ) Rat_ Ucn ( ortholog_one2one ) Rabbit_ UCN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRH |
| Tissue | NA |
| Tissue Specificity | Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481). {ECO:0000269|PubMed:10690896, ECO:0000269|PubMed:15531481}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2RMF (NMR - ) 3N96 (X-ray 2.75A ) 6PB0 (EM 3.00A ) 6PB1 (EM 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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