| Gene Information | |
|---|---|
| Gene Name | UCHL5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 329 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) |
| Target Name | ubiquitin c-terminal hydrolase uch37 |
| Target Type | Patented-recorded target |
| Gene Age | 1714 ( ENSG00000116750 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5K5 |
| Gene Card | UCHL5 |
| Uniprot ID | Q9Y5K5 |
| Pfam | PF01088; PF18031 |
| In ASD | yes |
| Allosteric Prediction | yes (0.318153271) |
| Ortholog in Animals | Alpaca_ UCHL5 ( ortholog_one2one ) Dog_ UCHL5 ( ortholog_one2one ) GuineaPig_ UCHL5 ( ortholog_one2one ) Macaque_ UCHL5 ( ortholog_one2one ) Mouse_ Uchl5 ( ortholog_one2one ) Pig_ UCHL5 ( ortholog_one2one ) Rat_ Uchl5 ( ortholog_one2one ) Rabbit_ UCHL5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UCHL1, BAP1, UCHL3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.104368(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3A7S (X-ray 2.20A ) 3IHR (X-ray 2.95A ) 3RII (X-ray 2.00A ) 3RIS (X-ray 2.40A ) 3TB3 (X-ray 2.30A ) 4UEL (X-ray 2.30A ) 4UEM (X-ray 2.82A ) 4UF5 (X-ray 3.70A ) 4UF6 (X-ray 3.69A ) 4WLP (X-ray 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18922472}. Nucleus {ECO:0000269|PubMed:18922472}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus. |
| Mouse PG classification | NA |
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