| Gene Information | |
|---|---|
| Gene Name | UCHL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 223 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) |
| Target Name | ubiquitin carboxyl-terminal hydrolase isozyme l1 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000154277 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P09936 |
| Gene Card | UCHL1 |
| Uniprot ID | P09936 |
| Pfam | PF01088 |
| In ASD | no |
| Allosteric Prediction | no (-0.230611811) |
| Ortholog in Animals | Alpaca_ UCHL1 ( ortholog_one2one ) GuineaPig_ UCHL1 ( ortholog_one2one ) Macaque_ UCHL1 ( ortholog_one2one ) Mouse_ Uchl1 ( ortholog_one2one ) Pig_ UCHL1 ( ortholog_one2one ) Rat_ Uchl1 ( ortholog_one2one ) Rabbit_ UCHL1 ( ortholog_one2one ) |
| Ohnologs | UCHL3 |
| Paralogs | BAP1, UCHL3, UCHL5 |
| Tissue | substantia.nigra |
| Tissue Specificity | Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. {ECO:0000269|PubMed:14722078, ECO:0000269|PubMed:9790970}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2ETL (X-ray 2.40A ) 2LEN (NMR - ) 3IFW (X-ray 2.40A ) 3IRT (X-ray 2.80A ) 3KVF (X-ray 2.80A ) 3KW5 (X-ray 2.83A ) 4DM9 (X-ray 2.35A ) 4JKJ (X-ray 2.15A ) |
| DBSNP | rs397515634 rs5030732 rs121917767 rs768996179 rs1057519600 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain. |
| Mouse PG classification | NA |
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