| Gene Information | |
|---|---|
| Gene Name | KSR |
| Organism | Homo sapiens (Human) |
| Gene Length | 923 |
| Protein Names | Kinase suppressor of Ras 1 (EC 2.7.11.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8IVT5 |
| Gene Card | KSR1 |
| Uniprot ID | Q8IVT5 |
| Pfam | PF07714; PF13543; PF20406 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VYK (X-ray 1.75A ) 7JUW (X-ray 2.88A ) 7JUX (X-ray 3.34A ) 7JUY (X-ray 3.10A ) 7JUZ (X-ray 3.21A ) 7JV0 (X-ray 3.63A ) 7JV1 (X-ray 3.62A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000269|PubMed:20679487}; Peripheral membrane protein {ECO:0000269|PubMed:20679487}. Cell membrane {ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305|PubMed:12007434}. |
| Mouse PG classification | NA |
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