| Gene Information | |
|---|---|
| Gene Name | UBR5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2799 |
| Protein Names | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000104517 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | UBR5 |
| Uniprot ID | O95071 |
| Pfam | PF11547; PF00632; PF00658 |
| In ASD | no |
| Allosteric Prediction | no (-0.413280647) |
| Ortholog in Animals | Alpaca_ UBR5 ( ortholog_one2one ) Dog_ UBR5 ( ortholog_one2one ) GuineaPig_ UBR5 ( ortholog_one2one ) Macaque_ UBR5 ( ortholog_one2one ) Mouse_ Ubr5 ( ortholog_one2one ) Pig_ UBR5 ( ortholog_one2one ) Rat_ Ubr5 ( ortholog_one2one ) Rabbit_ UBR5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. |
| Pharmacological Animal Models | 0.021592(Chimpanzee);0.013377(Mouse);NULL(Rat);0.032653(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1I2T (X-ray 1.04A ) 2QHO (X-ray 1.85A ) 3PT3 (X-ray 1.97A ) |
| DBSNP | rs1062822 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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