| Gene Information | |
|---|---|
| Gene Name | UBR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1755 |
| Protein Names | E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000024048 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IWV8 |
| Gene Card | UBR2 |
| Uniprot ID | Q8IWV8 |
| Pfam | PF02617; PF18995; PF02207 |
| In ASD | yes |
| Allosteric Prediction | yes (0.036679595) |
| Ortholog in Animals | Alpaca_ UBR2 ( ortholog_one2one ) Dog_ UBR2 ( ortholog_one2one ) GuineaPig_ UBR2 ( ortholog_one2one ) Macaque_ UBR2 ( ortholog_one2one ) Mouse_ Ubr2 ( ortholog_one2one ) Pig_ UBR2 ( ortholog_one2one ) Rat_ Ubr2 ( ortholog_one2one ) Rabbit_ UBR2 ( ortholog_one2one ) |
| Ohnologs | UBR1 |
| Paralogs | UBR1, UBR3 |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3NY2 (X-ray 2.61A ) 3NY3 (X-ray 1.60A ) 5TDA (X-ray 0.79A ) 5TDB (X-ray 1.10A ) 5TDD (X-ray 1.55A ) 5UM3 (X-ray 1.20A ) |
| DBSNP | rs6905054 rs6917033 rs6917033 rs6917033 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q6WKZ8}. Chromosome {ECO:0000250|UniProtKB:Q6WKZ8}. Note=Associated with chromatin during meiosis. {ECO:0000250|UniProtKB:Q6WKZ8}. |
| Mouse PG classification | NA |
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