Gene Information
Gene NameCACNA1A
OrganismHomo sapiens (Human)
Gene Length2506
Protein NamesVoltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)
Target Namevoltage-dependent p/q-type calcium channel subunit alpha-1a
Target TypeNA
Gene Age645 ( ENSG00000141837 )
Evolutionary StageVertebrata
AlphaFoldDBO00555
Gene CardCACNA1A
Uniprot IDO00555
PfamPF08763; PF16905; PF00520
In ASDno
Allosteric Predictionyes (0.909790307)
Ortholog in AnimalsAlpaca_ CACNA1A ( ortholog_one2one )
Dog_ CACNA1A ( ortholog_one2one )
GuineaPig_ CACNA1A ( ortholog_one2one )
Macaque_ CACNA1A ( ortholog_one2one )
Mouse_ Cacna1a ( ortholog_one2one )
Pig_ CACNA1A ( ortholog_one2one )
Rat_ Cacna1a ( ortholog_one2one )
Rabbit_ CACNA1A ( ortholog_one2one )
OhnologsCACNA1B, CACNA1E
ParalogsSCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
Tissuebrain, stomach, cerebellar.hemisphere, cerebellum
Tissue SpecificityBrain specific;
mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. {ECO:0000269|PubMed:1335101}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3BXK  (X-ray  2.55A  ) 
DBSNP rs15999  rs886037944  rs121908211  rs121908222  rs121908225  rs121908238  rs121908228  rs121908231  rs121908236  rs121908215  rs121908239  rs121908245  rs41276886  rs121908240  rs121908217  rs121908246  rs121908212  rs886037945  rs121908213  rs121908218  rs16019  rs121908241  rs121908242  rs16020  rs16022  rs16023  rs16024  rs16027  rs16028  rs121908223  rs1568473283  rs121908230  rs121908219  rs121908227  rs121908237  rs121908232  rs121908233  rs121908234  rs1131691374  rs886037946  rs1555740805  rs121908216  rs121908247  rs121908220  rs1057519429  rs121908243  rs121908221  rs121908224  rs121908229  rs121908226  rs121908214  rs121908244  rs121908235  rs16056 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10049321, ECO:0000269|PubMed:26716990};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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