Gene Information
Gene NameDHX36
OrganismHomo sapiens (Human)
Gene Length1008
Protein NamesATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)
Target NameNA
Target TypeNA
Gene Age1292 ( ENSG00000174953 )
3 ( ENSG00000281763 )
Evolutionary StageEukaryota
AlphaFoldDBQ9H2U1
Gene CardDHX36
Uniprot IDQ9H2U1
PfamPF00270; PF04408; PF00271; PF07717
In ASDno
Allosteric Predictionno (-0.970706424)
Ortholog in AnimalsAlpaca_ DHX36 ( ortholog_one2one )
Dog_ DHX36 ( ortholog_one2one )
GuineaPig_ DHX36 ( ortholog_one2one )
Macaque_ DHX36 ( ortholog_one2one )
Mouse_ Dhx36 ( ortholog_one2one )
Pig_ DHX36 ( ortholog_one2one )
Rat_ Dhx36 ( ortholog_one2one )
Rabbit_ DHX36 ( ortholog_one2one )
OhnologsNA
ParalogsYTHDC2, DHX40, DHX34, DHX32, HELB, DHX57, DHX30, DHX29, DHX15, DHX35, DHX9, DHX38, DQX1, DHX16, DHX33, TDRD9, DHX8, DHX37
TissueNA
Tissue SpecificityHighly expressed in testis. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2N16  (NMR  -  )  2N21  (NMR  -  )  6Q6R  (X-ray  1.50A  ) 
DBSNP rs1058299  rs9438  rs17853513 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18854321}. Cytoplasm {ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18854321}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8VHK9}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18854321}. Nucleus speckle {ECO:0000269|PubMed:18279852}. Chromosome, telomere {ECO:0000269|PubMed:20472641}. Mitochondrion {ECO:0000250|UniProtKB:Q8VHK9}. Perikaryon {ECO:0000250|UniProtKB:D4A2Z8}. Cell projection, dendrite {ECO:0000250|UniProtKB:D4A2Z8}. Cell projection, axon {ECO:0000250|UniProtKB:D4A2Z8}. Note=Predominantly localized in the nucleus (PubMed:18279852). Colocalizes with SRSF2 in nuclear speckles (PubMed:18279852). Colocalizes with DDX5 in nucleolar caps upon transcription inhibition (PubMed:18279852). Accumulates and colocalized with TIA1 in cytoplasmic stress granules (SGs) in an arsenite-, heat shock- and RNA-binding-dependent manner (PubMed:18854321). Shuttles into and out of SGs in an ATPase-dependent manner (PubMed:18854321). Colocalizes in the cytosol with the multi-helicase-TICAM1 complex that translocates to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18854321}.;
[Isoform 1]: Nucleus {ECO:0000269|PubMed:14731398}. Cytoplasm {ECO:0000269|PubMed:14731398}. Note=Preferentially localized in the nucleus (PubMed:14731398). Excluded from nucleoli (PubMed:14731398). {ECO:0000269|PubMed:14731398}.;
[Isoform 2]: Nucleus {ECO:0000269|PubMed:14731398}. Cytoplasm {ECO:0000269|PubMed:14731398}. Note=Preferentially localized in the cytoplasm (PubMed:14731398). Excluded from nucleoli (PubMed:14731398). {ECO:0000269|PubMed:14731398}.
Mouse PG classificationNA
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