| Gene Information | |
|---|---|
| Gene Name | IL1RL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 556 |
| Protein Names | Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000115602 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q01638 |
| Gene Card | IL1RL1 |
| Uniprot ID | Q01638 |
| Pfam | PF07679; PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-0.061458671) |
| Ortholog in Animals | GuineaPig_ IL1RL1 ( ortholog_one2one ) Macaque_ IL1RL1 ( ortholog_one2one ) Mouse_ Il1rl1 ( ortholog_one2one ) Pig_ IL1RL1 ( ortholog_one2one ) Rat_ Il1rl1 ( ortholog_one2one ) Rabbit_ IL1RL1 ( ortholog_one2one ) |
| Ohnologs | IL1RAPL2, IL1RAP |
| Paralogs | IL1R1, IL1RL2, LAG3, IL1R2, IL18R1, SIGIRR, IL18RAP, IL1RAPL1, IL1RAPL2, IL1RAP |
| Tissue | placenta, lung |
| Tissue Specificity | Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver. {ECO:0000269|PubMed:11478810, ECO:0000269|PubMed:19508382}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KC3 (X-ray 3.27A ) |
| DBSNP | rs1041973 rs4988956 rs10192036 rs10204137 rs10192157 rs10206753 |
| Subcellular location [CC] | [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |