| Gene Information | |
|---|---|
| Gene Name | ERCC6L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1561 |
| Protein Names | DNA excision repair protein ERCC-6-like 2 (EC 3.6.4.-) (DNA repair and recombination protein RAD26-like) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182150 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5T890 |
| Gene Card | ERCC6L2 |
| Uniprot ID | Q5T890 |
| Pfam | PF00271; PF00176; PF14773 |
| In ASD | no |
| Allosteric Prediction | no (-1.67362088) |
| Ortholog in Animals | Dog_ ERCC6L2 ( ortholog_one2one ) Macaque_ ERCC6L2 ( ortholog_one2one ) Pig_ ERCC6L2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in bone marrow (at protein level). {ECO:0000269|PubMed:24507776}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6HQ9 (X-ray 1.98A ) |
| DBSNP | rs2274654 |
| Subcellular location [CC] | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner. |
| Mouse PG classification | NA |
| click here to return to the previous page | |