| Gene Information | |
|---|---|
| Gene Name | UBA6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1052 |
| Protein Names | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000033178 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | A0AVT1 |
| Gene Card | UBA6 |
| Uniprot ID | A0AVT1 |
| Pfam | PF16191; PF16190; PF09358; PF00899; PF10585 |
| In ASD | yes |
| Allosteric Prediction | no (-0.297419608) |
| Ortholog in Animals | Alpaca_ UBA6 ( ortholog_one2one ) Dog_ UBA6 ( ortholog_one2one ) GuineaPig_ UBA6 ( ortholog_one2one ) Macaque_ UBA6 ( ortholog_one2one ) Mouse_ Uba6 ( ortholog_one2one ) Pig_ UBA6 ( ortholog_one2one ) Rat_ Uba6 ( ortholog_one2one ) Rabbit_ UBA6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBA7, UBA3, NAE1, UBA2, UBA1, UBA5, MOCS3, ATG7, SAE1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759}. |
| Pharmacological Animal Models | 0.014569(Chimpanzee);0.012719(Mouse);0.001240(Rat);0.039130(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 7PVN (X-ray 2.71A ) 7PYV (X-ray 3.27A ) |
| DBSNP | rs10010188 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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