| Gene Information | |
|---|---|
| Gene Name | UBA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000081307 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9GZZ9 |
| Gene Card | UBA5 |
| Uniprot ID | Q9GZZ9 |
| Pfam | PF00899 |
| In ASD | no |
| Allosteric Prediction | no (-0.665782474) |
| Ortholog in Animals | Alpaca_ UBA5 ( ortholog_one2one ) Dog_ UBA5 ( ortholog_one2one ) GuineaPig_ UBA5 ( ortholog_one2one ) Macaque_ UBA5 ( ortholog_one2one ) Mouse_ Uba5 ( ortholog_one2one ) Pig_ UBA5 ( ortholog_one2one ) Rat_ Uba5 ( ortholog_one2one ) Rabbit_ UBA5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBA7, UBA3, NAE1, UBA6, UBA2, UBA1, MOCS3, ATG7, SAE1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:16328888}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3GUC (X-ray 2.25A ) 3H8V (X-ray 2.00A ) 5HKH (X-ray 2.55A ) 5IA8 (X-ray 2.00A ) 5IAA (X-ray 1.85A ) 5L95 (X-ray 2.10A ) 6H77 (X-ray 2.10A ) 6H78 (X-ray 2.70A ) 6H8C (NMR - ) 7NVK (X-ray 2.65A ) 7NW1 (X-ray 1.95A ) 7OVC (NMR - ) |
| DBSNP | rs774318611 rs532178791 rs886039761 rs886039759 rs886039762 rs114925667 rs886039760 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:26872069}. Nucleus {ECO:0000269|PubMed:18442052}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30990354}. Golgi apparatus {ECO:0000269|PubMed:26872069}. Note=Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2 (PubMed:18442052). Interaction with GABARAPL2 promotes localization to the endoplasmic reticulum membrane (PubMed:30990354). {ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:30990354}. |
| Mouse PG classification | NA |
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