| Gene Information | |
|---|---|
| Gene Name | UBA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 463 |
| Protein Names | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000144744 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TBC4 |
| Gene Card | UBA3 |
| Uniprot ID | Q8TBC4 |
| Pfam | PF08825; PF00899 |
| In ASD | no |
| Allosteric Prediction | no (-0.2820747) |
| Ortholog in Animals | Alpaca_ UBA3 ( ortholog_one2one ) Dog_ UBA3 ( ortholog_one2one ) GuineaPig_ UBA3 ( ortholog_one2one ) Macaque_ UBA3 ( ortholog_one2one ) Mouse_ Uba3 ( ortholog_one2one ) Pig_ UBA3 ( ortholog_one2one ) Rat_ Uba3 ( ortholog_one2many ) Rabbit_ UBA3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBA7, NAE1, UBA6, UBA2, UBA1, UBA5, MOCS3, ATG7, SAE1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10207026}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1R4M (X-ray 3.00A ) 1R4N (X-ray 3.60A ) 1TT5 (X-ray 2.60A ) 1Y8X (X-ray 2.40A ) 1YOV (X-ray 2.60A ) 2LQ7 (NMR - ) 2NVU (X-ray 2.80A ) 3DBH (X-ray 2.85A ) 3DBL (X-ray 2.90A ) 3DBR (X-ray 3.05A ) 3FN1 (X-ray 2.50A ) 3GZN (X-ray 3.00A ) 5JJM (X-ray 2.15A ) |
| DBSNP | rs17852113 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
| click here to return to the previous page | |