| Gene Information | |
|---|---|
| Gene Name | UAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)] |
| Target Name | udp-n-acetylhexosamine pyrophosphorylase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000117143 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q16222 |
| Gene Card | UAP1 |
| Uniprot ID | Q16222 |
| Pfam | PF01704 |
| In ASD | no |
| Allosteric Prediction | no (-0.045699924) |
| Ortholog in Animals | Alpaca_ UAP1 ( ortholog_one2one ) Dog_ UAP1 ( ortholog_one2one ) GuineaPig_ UAP1 ( ortholog_one2one ) Macaque_ UAP1 ( ortholog_one2one ) Mouse_ Uap1 ( ortholog_one2one ) Pig_ UAP1 ( ortholog_one2one ) Rat_ Uap1 ( ortholog_one2many ) Rat_ AABR07063082.1 ( ortholog_one2many ) Rabbit_ UAP1 ( ortholog_one2one ) |
| Ohnologs | UAP1L1 |
| Paralogs | UAP1L1, UGP2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.848044(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JV1 (X-ray 1.90A ) 1JV3 (X-ray 2.20A ) 1JVD (X-ray 2.40A ) 1JVG (X-ray 2.30A ) 6Z2F (X-ray 1.70A ) |
| DBSNP | rs1128539 |
| Subcellular location [CC] | Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail. |
| Mouse PG classification | NA |
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