| Gene Information | |
|---|---|
| Gene Name | TZAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 688 |
| Protein Names | Telomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P10074 |
| Gene Card | ZBTB48 |
| Uniprot ID | P10074 |
| Pfam | PF00651; PF00096 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in adrenal gland and neuroblastoma. {ECO:0000269|PubMed:9516840}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3B84 (X-ray 1.74A ) 5YJ3 (X-ray 2.85A ) |
| DBSNP | rs2229330 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257}. Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257). {ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257}. |
| Mouse PG classification | NA |
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