| Gene Information | |
|---|---|
| Gene Name | OGDH |
| Organism | Homo sapiens (Human) |
| Gene Length | 1023 |
| Protein Names | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) |
| Target Name | alpha-ketoglutarate dehydrogenase |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000105953 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q02218 |
| Gene Card | OGDH |
| Uniprot ID | Q02218 |
| Pfam | PF16078; PF00676; PF16870; PF02779 |
| In ASD | no |
| Allosteric Prediction | yes (0.392750251) |
| Ortholog in Animals | Alpaca_ OGDH ( ortholog_one2many ) Dog_ OGDH ( ortholog_one2one ) GuineaPig_ OGDH ( ortholog_one2one ) Macaque_ OGDH ( ortholog_one2one ) Mouse_ Ogdh ( ortholog_one2one ) Pig_ OGDH ( ortholog_one2one ) Rat_ Ogdh ( ortholog_one2one ) Rabbit_ OGDH ( ortholog_one2one ) |
| Ohnologs | OGDHL |
| Paralogs | OGDHL, DHTKD1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.031579(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ERY (X-ray 1.95A ) 7WGR (EM 2.92A ) |
| DBSNP | rs2070607 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:29211711}. Nucleus {ECO:0000269|PubMed:29211711}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}. |
| Mouse PG classification | LPG |
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