| Gene Information | |
|---|---|
| Gene Name | TYRO3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 890 |
| Protein Names | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) |
| Target Name | tyrosine-protein kinase receptor tyro3 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000092445 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q06418 |
| Gene Card | TYRO3 |
| Uniprot ID | Q06418 |
| Pfam | PF00041; PF07679; PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.263316595) |
| Ortholog in Animals | Alpaca_ TYRO3 ( ortholog_one2one ) Dog_ TYRO3 ( ortholog_one2one ) GuineaPig_ TYRO3 ( ortholog_one2one ) Macaque_ TYRO3 ( ortholog_one2one ) Mouse_ Tyro3 ( ortholog_one2one ) Pig_ TYRO3 ( ortholog_one2one ) Rat_ Tyro3 ( ortholog_one2one ) Rabbit_ TYRO3 ( ortholog_one2one ) |
| Ohnologs | AXL, MERTK |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Abundant in the brain and lower levels in other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1RHF (X-ray 1.96A ) |
| DBSNP | rs17854578 rs12148316 rs17857363 rs1042057 rs17854579 rs17857364 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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