| Gene Information | |
|---|---|
| Gene Name | TYR |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) |
| Target Name | tyrosinase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000077498 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P14679 |
| Gene Card | TYR |
| Uniprot ID | P14679 |
| Pfam | PF00264 |
| In ASD | yes |
| Allosteric Prediction | yes (0.506733704) |
| Ortholog in Animals | Alpaca_ TYR ( ortholog_one2one ) Dog_ TYR ( ortholog_one2one ) GuineaPig_ TYR ( ortholog_one2one ) Macaque_ TYR ( ortholog_one2one ) Mouse_ Tyr ( ortholog_one2one ) Pig_ TYR ( ortholog_one2one ) Rat_ Tyr ( ortholog_one2one ) Rabbit_ TYR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TYRP1, DCT |
| Tissue | skin |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.350650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs61753177 rs61753178 rs61753179 rs28940878 rs755700581 rs61753180 rs61753181 rs61753182 rs28940879 rs61753185 rs61753184 rs544053015 rs61753188 rs28940876 rs28940877 rs137854890 rs61753252 rs61753253 rs33955261 rs11545463 rs145513733 rs61753259 rs138487695 rs779878377 rs1042602 rs750553908 rs1338186937 rs61754362 rs28940880 rs61754363 rs63159160 rs61754365 rs63159160 rs61754367 rs774670098 rs61754369 rs61754370 rs62645902 rs104894314 rs1463109821 rs1468041471 rs1565391875 rs757754120 rs200854796 rs61754375 rs61754374 rs1042608 rs61754377 rs61754378 rs61754379 rs61754380 rs372534292 rs62645906 rs62645907 rs773970123 rs62645908 rs151206295 rs61754383 rs776054795 rs61754385 rs61754387 rs61754386 rs61754388 rs61754391 rs104894315 rs121908011 rs62645914 rs752344007 rs62645916 rs1126809 rs104894316 rs62645920 rs104894313 rs61754392 rs61754393 rs758747581 rs1362285246 rs281865325 rs281865327 rs104894317 rs104894318 rs1050708792 |
| Subcellular location [CC] | Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000250|UniProtKB:P11344}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P11344}. |
| Mouse PG classification | HPG |
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