| Gene Information | |
|---|---|
| Gene Name | TYMS |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) |
| Target Name | thymidylate synthase |
| Target Type | Clinical trial target |
| Gene Age | 1292 ( ENSG00000176890 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P04818 |
| Gene Card | TYMS |
| Uniprot ID | P04818 |
| Pfam | PF00303 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000079145) |
| Ortholog in Animals | Alpaca_ TYMS ( ortholog_one2one ) Dog_ TYMS ( ortholog_one2one ) GuineaPig_ TYMS ( ortholog_one2one ) Macaque_ TYMS ( ortholog_one2one ) Mouse_ Tyms ( ortholog_one2one ) Pig_ TYMS ( ortholog_one2one ) Rat_ Tyms ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DHFR, DHFR2 |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);0.015385(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HVY (X-ray 1.90A ) 1HW3 (X-ray 2.00A ) 1HW4 (X-ray 2.06A ) 1HZW (X-ray 2.00A ) 1I00 (X-ray 2.50A ) 1JU6 (X-ray 2.89A ) 1JUJ (X-ray 3.00A ) 1YPV (X-ray 1.80A ) 2ONB (X-ray 2.70A ) 2RD8 (X-ray 2.50A ) 2RDA (X-ray 2.67A ) 3EAW (X-ray 1.86A ) 3EBU (X-ray 2.05A ) 3ED7 (X-ray 1.56A ) 3EDW (X-ray 1.75A ) 3EF9 (X-ray 3.20A ) 3EGY (X-ray 2.18A ) 3EHI (X-ray 2.00A ) 3EJL (X-ray 3.20A ) 3GG5 (X-ray 2.77A ) 3GH0 (X-ray 1.56A ) 3GH2 (X-ray 1.75A ) 3H9K (X-ray 2.65A ) 3HB8 (X-ray 2.74A ) 3N5E (X-ray 2.26A ) 3N5G (X-ray 2.27A ) 3OB7 (X-ray 2.75A ) 4E28 (X-ray 2.30A ) 4FGT (X-ray 2.00A ) 4G2O (X-ray 2.25A ) 4G6W (X-ray 2.30A ) 4GD7 (X-ray 2.29A ) 4GYH (X-ray 3.00A ) 4H1I (X-ray 3.10A ) 4JEF (X-ray 2.31A ) 4KPW (X-ray 2.03A ) 4O1U (X-ray 2.26A ) 4O1X (X-ray 2.32A ) 4UP1 (X-ray 2.99A ) 5HS3 (X-ray 3.10A ) 5WRN (X-ray 2.39A ) 5X4W (X-ray 2.10A ) 5X4X (X-ray 2.31A ) 5X4Y (X-ray 2.20A ) 5X5A (X-ray 2.39A ) 5X5D (X-ray 2.00A ) 5X5Q (X-ray 2.79A ) 5X66 (X-ray 1.99A ) 5X67 (X-ray 2.13A ) 5X69 (X-ray 2.69A ) 6OJU (X-ray 2.88A ) 6OJV (X-ray 2.59A ) 6PF3 (X-ray 2.39A ) 6PF4 (X-ray 2.85A ) 6PF5 (X-ray 2.39A ) 6PF6 (X-ray 2.50A ) 6QXG (X-ray 2.08A ) 6QXH (X-ray 2.04A ) 6QYQ (X-ray 2.25A ) 6R2E (X-ray 2.55A ) 6ZXO (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:21876188}. Mitochondrion {ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}. |
| Mouse PG classification | NA |
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