| Gene Information | |
|---|---|
| Gene Name | TYK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1187 |
| Protein Names | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) |
| Target Name | tyk2 tyrosine kinase |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000105397 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P29597 |
| Gene Card | TYK2 |
| Uniprot ID | P29597 |
| Pfam | PF18379; PF18377; PF17887; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.039432656) |
| Ortholog in Animals | Alpaca_ TYK2 ( ortholog_one2one ) Dog_ TYK2 ( ortholog_one2one ) GuineaPig_ TYK2 ( ortholog_one2one ) Macaque_ TYK2 ( ortholog_one2one ) Mouse_ Tyk2 ( ortholog_one2one ) Pig_ TYK2 ( ortholog_one2one ) Rat_ Tyk2 ( ortholog_one2one ) Rabbit_ TYK2 ( ortholog_one2one ) |
| Ohnologs | JAK3, JAK2, JAK1 |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. {ECO:0000269|PubMed:2156206}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3LXN (X-ray 2.50A ) 3LXP (X-ray 1.65A ) 3NYX (X-ray 2.50A ) 3NZ0 (X-ray 2.00A ) 3ZON (X-ray 2.15A ) 4GFO (X-ray 2.30A ) 4GIH (X-ray 2.00A ) 4GII (X-ray 2.31A ) 4GJ2 (X-ray 2.40A ) 4GJ3 (X-ray 2.50A ) 4GVJ (X-ray 2.03A ) 4OLI (X-ray 2.80A ) 4PO6 (X-ray 1.99A ) 4PY1 (X-ray 2.16A ) 4WOV (X-ray 1.80A ) 5C01 (X-ray 2.15A ) 5C03 (X-ray 1.90A ) 5F1Z (X-ray 2.65A ) 5F20 (X-ray 2.91A ) 5TKD (X-ray 1.92A ) 5WAL (X-ray 2.45A ) 6AAM (X-ray 1.98A ) 6DBK (X-ray 2.00A ) 6DBM (X-ray 2.37A ) 6NSL (X-ray 2.15A ) 6NZE (X-ray 1.96A ) 6NZF (X-ray 2.39A ) 6NZH (X-ray 2.73A ) 6NZP (X-ray 2.35A ) 6NZQ (X-ray 2.11A ) 6NZR (X-ray 2.56A ) 6OVA (X-ray 2.50A ) 6VNS (X-ray 2.09A ) 6VNV (X-ray 2.15A ) 6VNX (X-ray 2.18A ) 6VNY (X-ray 2.30A ) 6X8F (X-ray 2.15A ) 6X8G (X-ray 2.21A ) 7AX4 (X-ray 2.12A ) 7K7O (X-ray 2.82A ) 7K7Q (X-ray 2.27A ) 7UYR (X-ray 2.15A ) 7UYS (X-ray 2.15A ) 7UYT (X-ray 2.14A ) 7UYU (X-ray 2.05A ) |
| DBSNP | rs12720343 rs1049619 rs12720263 rs2304256 rs2304255 rs55956017 rs2304254 rs12720356 rs55882956 rs34046749 rs35018800 rs34536443 rs55886939 |
| Subcellular location [CC] | NA |
| Mouse PG classification | LPG |
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