| Gene Information | |
|---|---|
| Gene Name | TXNRD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 643 |
| Protein Names | Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000197763 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | NA |
| Gene Card | TXNRD3 |
| Uniprot ID | Q86VQ6 |
| Pfam | PF00462; PF07992; PF02852 |
| In ASD | no |
| Allosteric Prediction | yes (0.154028357) |
| Ortholog in Animals | Alpaca_ TXNRD3 ( ortholog_one2one ) Dog_ TXNRD3 ( ortholog_one2one ) GuineaPig_ TXNRD3 ( ortholog_one2one ) Macaque_ TXNRD3 ( ortholog_one2one ) Mouse_ Txnrd3 ( ortholog_one2one ) Pig_ TXNRD3 ( ortholog_one2one ) Rat_ Txnrd3 ( ortholog_one2one ) Rabbit_ TXNRD3 ( ortholog_one2one ) |
| Ohnologs | TXNRD1 |
| Paralogs | AIFM3, AIFM1, PYROXD1, DLD, TXNRD2, TXNRD1, GSR |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3H8Q (X-ray 2.21A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum {ECO:0000250}. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250|UniProtKB:Q99MD6}. |
| Mouse PG classification | NA |
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