| Gene Information | |
|---|---|
| Gene Name | KIAA1048 |
| Organism | Homo sapiens (Human) |
| Gene Length | 961 |
| Protein Names | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q2M2I8 |
| Gene Card | AAK1 |
| Uniprot ID | Q2M2I8 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain. {ECO:0000269|PubMed:17494869}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4WSQ (X-ray 1.95A ) 5L4Q (X-ray 1.97A ) 5TE0 (X-ray 1.90A ) |
| DBSNP | rs34535244 rs6715776 rs1263928487 rs56038532 rs55889248 rs35285785 rs34422616 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:F1MH24}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1MH24}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:11877461}. Presynapse {ECO:0000250|UniProtKB:P0C1X8}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. {ECO:0000250|UniProtKB:P0C1X8}. |
| Mouse PG classification | NA |
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