| Gene Information | |
|---|---|
| Gene Name | TXNDC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 127 |
| Protein Names | Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000204193 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q6A555 |
| Gene Card | TXNDC8 |
| Uniprot ID | Q6A555 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | no (-1.428784146) |
| Ortholog in Animals | Alpaca_ TXNDC8 ( ortholog_one2one ) Macaque_ TXNDC8 ( ortholog_one2one ) Mouse_ Txndc8 ( ortholog_one2one ) Rat_ Txndc8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TXNL1, TXNDC2, TXN, TXN2 |
| Tissue | testis |
| Tissue Specificity | Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). {ECO:0000269|PubMed:15181017}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7041938 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15181017}. Golgi apparatus {ECO:0000269|PubMed:15181017}. |
| Mouse PG classification | NA |
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