| Gene Information | |
|---|---|
| Gene Name | TXNDC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 553 |
| Protein Names | Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000168454 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q86VQ3 |
| Gene Card | TXNDC2 |
| Uniprot ID | Q86VQ3 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | no (-1.292910878) |
| Ortholog in Animals | Alpaca_ TXNDC2 ( ortholog_one2one ) Macaque_ TXNDC2 ( ortholog_one2one ) Mouse_ Txndc2 ( ortholog_one2one ) Rat_ Txndc2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TXNDC8, TXNL1, TXN, TXN2 |
| Tissue | testis |
| Tissue Specificity | Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids. {ECO:0000269|PubMed:11399755}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11662946 rs2240909 rs11081510 rs2240906 rs17732496 rs17805544 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11399755}. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece. |
| Mouse PG classification | NA |
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