| Gene Information | |
|---|---|
| Gene Name | TXN |
| Organism | Homo sapiens (Human) |
| Gene Length | 105 |
| Protein Names | Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx) |
| Target Name | thioredoxin |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000136810 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P10599 |
| Gene Card | TXN |
| Uniprot ID | P10599 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | yes (0.372042174) |
| Ortholog in Animals | Alpaca_ TXN ( ortholog_one2one ) Mouse_ Txn1 ( ortholog_one2one ) Rat_ Txn1 ( ortholog_one2one ) Rabbit_ TXN ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | TXNDC8, TXNL1, TXNDC2, TXN2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.008713(Chimpanzee);0.009400(Mouse);0.001990(Rat);0.026667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AIU (X-ray 2.00A ) 1AUC (X-ray 2.10A ) 1CQG (NMR - ) 1CQH (NMR - ) 1ERT (X-ray 1.70A ) 1ERU (X-ray 2.10A ) 1ERV (X-ray 1.65A ) 1ERW (X-ray 1.80A ) 1M7T (NMR - ) 1MDI (NMR - ) 1MDJ (NMR - ) 1MDK (NMR - ) 1TRS (NMR - ) 1TRU (NMR - ) 1TRV (NMR - ) 1TRW (NMR - ) 2HSH (X-ray 1.35A ) 2HXK (X-ray 1.65A ) 2IFQ (X-ray 1.20A ) 2IIY (X-ray 1.70A ) 3E3E (X-ray 2.01A ) 3KD0 (X-ray 1.70A ) 3M9J (X-ray 1.10A ) 3M9K (X-ray 1.50A ) 3QFA (X-ray 2.20A ) 3QFB (X-ray 2.60A ) 3TRX (NMR - ) 4LL1 (X-ray 2.00A ) 4LL4 (X-ray 2.70A ) 4OO4 (X-ray 0.97A ) 4OO5 (X-ray 1.54A ) 4POK (X-ray 2.52A ) 4POL (X-ray 2.80A ) 4POM (X-ray 1.85A ) 4PUF (X-ray 3.30A ) 4TRX (NMR - ) 5DQY (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|PubMed:9108029}. |
| Mouse PG classification | NA |
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