Gene Information
Gene NameTXN
OrganismHomo sapiens (Human)
Gene Length105
Protein NamesThioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Target Namethioredoxin
Target TypeNA
Gene Age454 ( ENSG00000136810 )
Evolutionary StageEukaryota
AlphaFoldDBP10599
Gene CardTXN
Uniprot IDP10599
PfamPF00085
In ASDno
Allosteric Predictionyes (0.372042174)
Ortholog in AnimalsAlpaca_ TXN ( ortholog_one2one )
Mouse_ Txn1 ( ortholog_one2one )
Rat_ Txn1 ( ortholog_one2one )
Rabbit_ TXN ( ortholog_one2many )
OhnologsNA
ParalogsTXNDC8, TXNL1, TXNDC2, TXN2
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.008713(Chimpanzee);0.009400(Mouse);0.001990(Rat);0.026667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AIU  (X-ray  2.00A  1AUC  (X-ray  2.10A  1CQG  (NMR  1CQH  (NMR  1ERT  (X-ray  1.70A  1ERU  (X-ray  2.10A  1ERV  (X-ray  1.65A  1ERW  (X-ray  1.80A  1M7T  (NMR  1MDI  (NMR  1MDJ  (NMR  1MDK  (NMR  1TRS  (NMR  1TRU  (NMR  1TRV  (NMR  1TRW  (NMR  2HSH  (X-ray  1.35A  2HXK  (X-ray  1.65A  2IFQ  (X-ray  1.20A  2IIY  (X-ray  1.70A  3E3E  (X-ray  2.01A  3KD0  (X-ray  1.70A  3M9J  (X-ray  1.10A  3M9K  (X-ray  1.50A  3QFA  (X-ray  2.20A  3QFB  (X-ray  2.60A  3TRX  (NMR  4LL1  (X-ray  2.00A  4LL4  (X-ray  2.70A  4OO4  (X-ray  0.97A  4OO5  (X-ray  1.54A  4POK  (X-ray  2.52A  4POL  (X-ray  2.80A  4POM  (X-ray  1.85A  4PUF  (X-ray  3.30A  4TRX  (NMR  5DQY  (X-ray  1.40A 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|PubMed:9108029}.
Mouse PG classificationNA
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