| Gene Information | |
|---|---|
| Gene Name | TXK |
| Organism | Homo sapiens (Human) |
| Gene Length | 527 |
| Protein Names | Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) |
| Target Name | tyrosine-protein kinase txk |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000074966 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42681 |
| Gene Card | TXK |
| Uniprot ID | P42681 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.284973611) |
| Ortholog in Animals | Alpaca_ TXK ( ortholog_one2one ) Alpaca_ TXK ( ortholog_one2many ) Dog_ TXK ( ortholog_one2one ) GuineaPig_ TXK ( ortholog_one2one ) Mouse_ Txk ( ortholog_one2one ) Pig_ TXK ( ortholog_one2one ) Rat_ Txk ( ortholog_one2one ) Rabbit_ TXK ( ortholog_one2one ) |
| Ohnologs | BTK, ITK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:7951233}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DM0 (NMR - ) |
| DBSNP | rs7658300 rs41265727 rs11724347 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells. |
| Mouse PG classification | NA |
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